History of Fibromylgia

Significant developments in more than 400 years
Sometimes we hear about fibromyalgia as a “fashionable diagnosis” or “new disease,” but the truth is that fibromyalgia is far from new. It threw an ancient story, with many name changes and theories on the way.
Although not always accepted by the medical community, and today its acceptance is not universal, fibromyalgia has come a long way and current research continues to prove that it is a very real physiological disease.

The most frequently mentioned historical record of fibromyalgia comes from an article in 2004 by researchers Fatma Mohammed B. Yunus and Inanici. This story was compiled from their work, as well as new information from the last decade. (All sources are cited at the end of the article.)
Top – 1592-1900
From the beginning, doctors are not distinct definitions of all the conditions of pain that we know today. Definitions and terminology began on a large scale and gradually.
In 1592, French physician William de Baillou introduced the term “arthritis” refers to the musculus skeletal pain just described from an injury. This was a term that would have been recognized and fibromyalgia, arthritis and many other diseases. Finally, doctors have begun to use the cause of “muscular rheumatism” for painful conditions such as fibromyalgia, need for deformation.
Two hundred years later, the definitions are still rather vague.
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However, in 1815, the Scottish surgeon William Balfour nodules observed in the connective tissue and the theory that inflammation can be behind the nodules and pain. These are the first sensitive points (which will then be used for the diagnosis of fibromyalgia) describe.
A few decades later, the French physician Francois Valleix used to describe the term “neuralgia” that he believed pain of the sensitive points mentioned along the nerves.

Other theories of the day included hyperactive nerve endings or problems with the muscles themselves.
In 1880, American neurologist George William Beard neurasthenia invented to describe conditions and myelasthenia generalized pain, as well as fatigue and mental disorders. He believed that the disease was caused by stress.

1900 – 1975
Creation of a more specific terminology really exploded at the beginning of the 20th century. The different names for fibromyalgia disease like the following:
• Myogeloses
• Muscle hardening
• Fibrosite
Fibrosite, invented in 1904 by the British neurologist Sir William Gowers, is the one that remained. Gowers said by the symptoms seem familiar to people with fibromyalgia:
• Spontaneous pain,
• Sensitivity to pressure,
• Tired,
• Sleep disorders,
• Sensitivity to cold
• aggravation of symptoms through excessive use of muscles.
If the treatment, he suggested cocaine injections that the cocaine is then used as a local anesthetic.
Medical, “fibro” means connective tissue, and “itis” means inflammation. Shortly after Gowers submit the name, another researcher published a study that seems to confirm most Gowers theories about the mechanisms of inflammation in the disease. This allowed cement, the term fibrositis in the vernacular. Ironically, was later discovered another defective study.

In the 1930s, interest increased in muscle pain returned by soft spots / triggers and graphs of these models began to appear. Injections of local anesthesia remains a proposed treatment.
The diagnosis of fibrosis was not uncommon at that time. A 1936 paper reported that fibrosis is the most common form of severe chronic rheumatism. He also said that in the UK, it accounts for 60 percent of rheumatic disease insurance cases.
In addition, at that time, the concept of muscle pain has been found behind the research. One study of pain pathways is deep pain and hyperalgesia (increased responsiveness to pain) and perhaps the first to suggest that the central nervous system was involved in the disease.
In addition, there is a document in trigger points, and pain reported exposing the term “myofascial pain syndromes” for localized pain.
Researchers suggested that generalized fibrosis pain may come from a person with several cases of myofascial pain syndrome.
World War II brought renewed attention when doctors discovered that soldiers were especially prone to fibrosis. Because they showed no signs of inflammation or physical degeneration and symptoms appeared related to stress and depression, researchers have called “psychogenic rheumatism”. A 1937 study suggested that fibrosis was a “chronic psychoneurotic state.” Therefore, the phase of the debate was born between the physical and psychological.
Fibrositis continued to be accepted, although doctors could not agree on exactly what it was. In 1949, a chapter on the topic appeared in well-considered rheumatology textbook titled arthritis and related diseases. It reads: “There can be no doubt about the existence of such a condition.” He mentioned a number of possible causes, including:
• Infections
• traumatic or professional
• Climate factors,
• metal disorder.
However, the descriptions were vague boobs that we now recognize that includes a number of very different types of pain issues. Usually involved include fatigue, headaches and psychological disorders, but lack of sleep was not mentioned.
The first description of fibrosis similar to what we know today as fibromyalgia was called in 1968. The document investigator Eugene F. Traut:
• generalized pain and stiffness,
• Fatigue,
• Headache,
• Colitis,
• Lack of sleep,
• To be “worried,” ”
• The trend point discovered the physical examination,
• An important body-mind connection.

In addition to the pain in general, he acknowledged that some areas are compliance, including what we now know as carpal tunnel syndrome. He mentioned “the different levels of the vortex axis,” he is recognized the modern diagnostic criteria: pain in the axial skeleton (bones of the head, throat, chest and spine) and in four quadrants body.
Four years later, researcher Hugh A. Smythe writes a section on fibrosis in the manual, which had a great influence on future studies, which his “grandfather of modern fibromyalgia.” He is believed to be the first to describe A common condition, which differentiates myfasciaal pain syndrome.
Smythe included not only lack of sleep in the description, but described how sleep was patient and gave unpublished results electroencephalogram (sleep study) showed a dysfunction in sleep stages 3 and 4 steps. He further stated that non-restorative sleep, trauma and emotional distress, while they could lead to an increase in symptoms.
Further research confirmed sleep disturbances and it was found that sleep disorders can cause fibromyalgia-like symptoms in healthy people.
Then Smythe participated in a study that suggests more precise soft spots and proposes its use in diagnosis. He also referred to chronic pain, sleep disorders, morning stiffness and fatigue symptoms that can diagnose the disease.
• Next: 1976-present
1976 – Present
Although the researchers have made great strides, they still had not found any sign of inflammation – the “itis” in fibrosis. Then the name was changed to fibromyalgia “fibro” means connective tissue, “mi” means muscular and “neuralgia” means pain.
There are still many questions. The main symptoms are vague and common in the population. Doctors still had no control over what fibromyalgia was.
Then in 1981 came an original study of Muhammad Yunus. It was confirmed that pain, sleep disorders and fatigue were greater among people with fibromyalgia than in healthy control subjects; The number of bidding points was much larger; And several other symptoms were also more often. These additional symptoms include:
• subjective swelling,
• paresthesias (abnormal sensations of the nerves)
• Overlap irritable disorders such as bowel syndrome (IBS), tension headaches and migraines.

In this article we have set up sufficiently coherent group symptoms of fibromyalgia to name a syndrome as well as the first criterion that seemed to differ from other people with fibromyalgia.
A state study has already confirmed that these symptoms and conditions are overlapping, in fact, associated with fibromyalgia.
Yunus then conducted a research on the idea of ​​a number of overlapping conditions, primary dysmenorrhea (painful period) along with IBS, tension headaches and migraines.
It is believed that the unifying function was muscle cramps, but suggests that subsequently lead to central sensitization theory.
From there, we did a lot of research and development published. We do not have all the answers, but they gave us much better understanding of what goes on in our bodies.
Important perspectives are:
• 1984 – First study published this higher prevalence of fibromyalgia in relation to those suffering from rheumatoid arthritis;
• 1985 – The first controlled study of young fibromyalgia is published;
• 1986 – drugs that affect serotonin and norepinephrine, shown first to be effective;
• 1990 – American College of Rheumatology offers official diagnostic criteria for generalized pain and sensitivity in at least 11 of 18 specific points, to standardize inclusion criteria in the study worldwide;
• 1991 – Fibromyalgia impact questionnaire developed for physicians to evaluate function;
• 1992 – Discover Low levels of growth hormones;
• 1993 – Studies show central sensitization and HPA axis (stress management) abnormalities are in;
• 1994 – Confirmation of the substance of high P (messenger pain) in the cerebrospinal fluid;
• 1995 – First American study shows the prevalence of fibromyalgia in 2% of the population;
• 1995 – First SPECT (neuroimaging) showing the abnormal patterns of blood flow in the brain;
• 1999 – The first study in which the genetic component is shown to explain why it occurs in families;
• 2000 – Review of evidence, termination of central sensitization syndromes;
• 2005 – American Pain Society offers the first guidelines for the treatment of fibromyalgia pain;
• 2007 – Lyrica (pregabalin) is the first FDA treatment in the United States approved (in 2008 and 2009 Cymbalta (duloxetine) and Savella (milnacipran), respectively)
• 2010 – American College of Rheumatology diagnostic criteria indicates another use of these questionnaires rather than access points.
The search continued these results and proposes new factors and possible causal mechanisms. Since the beginning of 2014 questionnaires contain:
Inflammation of the fascia: Some studies have suggested that the widespread pain of fibromyalgia may be inflammatory, but the extremely thin connective tissue called fascia.
Additional nerves on blood vessels: A study shows common analgesics of temperature and additional nerves in the circulatory system.
small fiber nephropathy: New studies have shown that certain specialized nerves can be damaged.
• Immune system disorders: Some lines of research show abnormal activity in the immune system that can lead to chronic immune autoimmunity and activation. One study suggests an autoimmune reaction to serotonin. Another suggests a potential diagnostic test based on the immune profile.
Several researchers are also working to develop fibromyalgia subgroups, and they believe the key is to ignore the underlying mechanisms and better treatments. The treatments are still under investigation, and a major objective diagnostic tools target identified whenever a blood analysis or analysis.
Fibromyalgia has not found universal acceptance in the medical community, but it is closer than ever. As research continues to prove that it is both real and physiologically, this condition will have credibility and those of us will gain understanding, respect and, above all, better treatment options so that we can reclaim our future